JAHA:未复发的年轻卒中幸存者不良结局长期风险分析

2018-12-19 xing.T MedSci原创

由此可见,与匹配的对照者相比,年轻稳定卒中/短暂性脑缺血发作幸存者表现出不良结局的长期风险高于老年患者。研究结果支持年轻幸存者需要长期随访和积极降低风险,并建议对这些患者采取二级预防。

大约8%至21%的卒中发生在小于45岁的成年人中。虽然早期卒中复发的风险最大,但没有早期并发症的年轻幸存者的长期风险尚不清楚。

近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,该研究为纵向匹配病例对照研究(2003-2013)。连续就诊的缺血性卒中或短暂性脑缺血发作(年轻,≤44岁)的患者从加拿大安大略省的急诊或区域性卒中中心出院,无死亡、复发性卒中/短暂性脑缺血发作、心肌梗死、全因住院或入住长期或持续护理机构(≤90天),并以10:1匹配年龄(±1岁)、性别、收入、地理和病例日期(±50天)的一般人群的对照者。该研究的主要结局是死亡、卒中、心肌梗死以及1年、3年和5年入住长期或持续护理机构的综合结局。

在1年(2.2% vs. 9.9%)、3年(4.7% vs. 24.6%)和5年(7.1% vs. 37.2%)时,年轻卒中/短暂性脑缺血发作患者的绝对事件发生率低于老年患者。然而,分段恒定风险模型显示,即使在调整血管合并症后,年轻患者的复合结局风险比在1年时相比于年轻对照者增加7倍(风险比为7.3; 95%CI为4.0-13.6) 。调整后的5年分段风险也超过年轻对照者的5倍(风险比为5.2; 95%CI为2.8-9.4),而对于老年患者在5年时增加30%(风险比为1.3; 95%CI为1.3-1.4)。

由此可见,与匹配的对照者相比,年轻稳定卒中/短暂性脑缺血发作幸存者表现出不良结局的长期风险高于老年患者。研究结果支持年轻幸存者需要长期随访和积极降低风险,并建议对这些患者采取二级预防

原始出处:

Jodi D.et al.Young Stroke Survivors With No Early Recurrence at High Long‐Term Risk of Adverse Outcomes.JAHA.2018.https://www.ahajournals.org/doi/10.1161/JAHA.118.010370

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  2. [GetPortalCommentsPageByObjectIdResponse(id=2018366, encodeId=3bc420183667d, content=<a href='/topic/show?id=5cac36039a1' target=_blank style='color:#2F92EE;'>#卒中幸存者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36039, encryptionId=5cac36039a1, topicName=卒中幸存者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6393434, createdName=ailian1202, createdTime=Tue Aug 20 21:24:00 CST 2019, time=2019-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356050, encodeId=2ef6356050f1, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Fri Dec 21 23:38:40 CST 2018, time=2018-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268011, encodeId=0ec412680118d, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Fri Dec 21 14:24:00 CST 2018, time=2018-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401342, encodeId=1c6e1401342bf, content=<a href='/topic/show?id=80e89e0479a' target=_blank style='color:#2F92EE;'>#长期风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97047, encryptionId=80e89e0479a, topicName=长期风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Fri Dec 21 14:24:00 CST 2018, time=2018-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026244, encodeId=533c102624430, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Thu Dec 20 02:24:00 CST 2018, time=2018-12-20, status=1, ipAttribution=)]
    2018-12-21 清风拂面

    谢谢分享学习

    0

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    2018-12-21 zhaohui6731
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    2018-12-20 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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