Cell Reports:如何保住你可怜的发量?Cell子刊揭示毛发再生潜能新机制!

2021-06-16 生物探索 生物探索

防脱发的良方

不知何时开始,年轻人变成了脱发的主力军,开始提前感受“中年危机”。据国家卫健委2019年的调查数据显示,我国脱发人数已超2.5亿,比上一代人的脱发年龄提前了20年。显而易见,脱发俨然已经变成了一种无法挽回的潮流。为此,人们开始煞费苦心寻找治疗脱发的良方。

近日,中国科学院的科研人员在国际知名期刊《Cell Reports》杂志在线发表了一篇题为miR-24 controls the regenerative competence of hair follicle progenitors by targeting Plk3的文章,揭示了一种miRNA介导的皮肤毛囊(HF)前体细胞再生机制,为治疗脱发的思路提供重要线索。

众所周知,新发的生长是由毛囊成体干细胞(HFSC)所驱动的,因此,成体干细胞(SCs)作为再生医疗界的明星,由于具有超群的自我更新能力,近年来一直是人类生发事业的主力军。

正常情况下,成体干细胞是长期处于冬眠状态的,当接收到外界的再生信号时,才会恢复活力。因此,对于成体干细胞而言,时刻保持对周围微环境的敏感性至关重要,但如何调动毛囊成体干细胞对生长刺激的内在敏感性目前尚不明确。为此,在这项最新的研究中,科研人员对这个问题进行了深入的探索。

为了找出可能参与调节体内毛囊成体干细胞中的毛胚(HG)生长的关键因子,研究人员利用荧光激活细胞分选技术 (FACS)分离了HG细胞,并对富含HFSC的miRNA进行qRT-PCR分析。研究数据显示,miR-24在毛囊激活过程中显着下调,这进一步支持了miR-24是皮肤毛囊(HF)前体细胞激活的负调节因子的观点。

miR-24表达与HF祖细胞激活呈负相关

不仅如此,经过进一步的验证发现,在缺乏生长因子的培养环境下,小鼠表皮角化细胞 (MK)中的miR-24会先显着上调,且miR-24在MK中的过表达会延缓毛囊前体细胞的激活与毛发周期推进,相反,如果将该基因敲除,毛发周期就会被缩短。这说明miR-24的消融将增强皮肤上皮细胞对生长刺激的敏感性。

miR-24限制了 HF 祖细胞对生长刺激的敏感性

那么,引起这一系列反应的核心人物是谁呢?科研人员基于RNA-seq观察了一系列miR-24相关的基因表达变化,发现了一种重要的miR-24靶标“Plk3蛋白”。通过体内与体外的双重验证结果显示,该蛋白能“挽救”因miR-24过表达引起的生长竞争劣势,并作为 HF 前体细胞体内生长能力的关键性miR-24靶标。

Plk3是调节 HF 祖细胞生长能力的关键miR-24靶标

值得一提的是,该研究还针对美国食品药品监督管理局(FDA)批准的脱发药物米诺地尔(minoxidil)进行了验证,研究显示,抑制miR-24过表达可显着提高米诺地尔(minoxidil)的疗效,这进一步证明了miR-24具有作为新型生发治疗靶点的潜力。

米诺地尔(minoxidil)的疗效

总而言之,该项研究提示了miR-24可作为限制皮肤毛囊前体细胞再生潜能的一个关键因子,为治疗脱发提供了新的思路,期待未来人类的“头等大事”能尽快解决,不再愁于脱发。

原始出处:

Fengzhen Liu, et al. miR-24 controls the regenerative competence of hair follicle progenitors by targeting Plk3. Cell Reports, 2021.

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    2022-03-22 维他命
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    2021-07-13 ms3000001849118241

    学到了,表示期待未来

    0

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    2021-06-20 jijin198608

    学习了

    0

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    2021-06-17 14775a26m11暂无昵称

    有救了,都来读phd

    0

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    2021-06-16 潇洒熊潇洒

    发际线有救了?

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1872232, encodeId=0b0318e223210, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Oct 28 09:40:30 CST 2021, time=2021-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1962543, encodeId=5103196254355, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Tue Mar 22 09:40:30 CST 2022, time=2022-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=999094, encodeId=df3c999094eb, content=学到了,表示期待未来, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6a1c5547638, createdName=ms3000001849118241, createdTime=Tue Jul 13 13:12:38 CST 2021, time=2021-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=975236, encodeId=4de29e52365b, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1b3e1413849, createdName=jijin198608, createdTime=Sun Jun 20 21:54:26 CST 2021, time=2021-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=974365, encodeId=391c9e43655d, content=有救了,都来读phd, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=c7ad5218670, createdName=14775a26m11暂无昵称, createdTime=Thu Jun 17 13:02:12 CST 2021, time=2021-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=974212, encodeId=16b29e42129e, content=发际线有救了?, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210616/24667e82dc474d438cfa366d65717d99/09c14ce461ef4dbdafbcf576c83c288f.jpg, createdBy=d3135527069, createdName=潇洒熊潇洒, createdTime=Wed Jun 16 21:54:48 CST 2021, time=2021-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1039425, encodeId=9d2610394251f, content=机制研究离临床仍然有距离,不过与临床结合思考,仍然有帮助的,不能仅仅是纯临床思维,转化思维同样重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=肿肿, createdTime=Wed Jun 16 13:40:30 CST 2021, time=2021-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=974056, encodeId=fe319e4056cf, content=积分, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5b255520900, createdName=ms7000001644417250, createdTime=Wed Jun 16 11:45:43 CST 2021, time=2021-06-16, status=1, ipAttribution=)]
    2021-06-16 肿肿

    机制研究离临床仍然有距离,不过与临床结合思考,仍然有帮助的,不能仅仅是纯临床思维,转化思维同样重要

    0

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    2021-06-16 ms7000001644417250

    积分

    0