JAMA Pediatr:脐带管理与早产儿不良预后

2021-03-15 MedSci原创 MedSci原创

与立即结扎脐带相比,延迟结扎脐带可降低早产儿死亡率,而延迟结扎和挤压脐带可降低早产儿脑室出血和红细胞输注风险

胎盘输血是指在胎儿出生后,立即将脐带血通过胎盘传递到新生儿体内,以增加新生儿的血容量。有研究认为,胎盘输血额外增加的血容量与降低早产儿不良事件风险相关。在许多医疗机构中,早产儿延迟结扎脐带(DCC,≥30s)是早产儿临床管理的重要部分。
近日研究人员开展系统综述及荟萃研究,比较了几种常见的新生儿脐带护理手段:立即结扎脐带(ICC)、延迟结扎脐带(DCC)与挤压脐带(UCM)对早产儿预后的影响
研究人员收集了截至2020年9月,收录于PubMed、Embase、CINAHL和Cochrane的相关研究报道,涉及不同早产儿脐带管理方式对预后影响的研究。研究的主要终点为早产儿死亡,次要终点为脑室出血、严重脑室出血、需要红细胞输注以及其他新生儿疾病。
 
本次荟萃研究纳入56个临床研究,包含6852名早产儿,与ICC相比,DCC组早产儿的死亡率(22个研究,3083名患儿,7.6% vs 5.0%,OR=0.64)、脑室出血风险(25个研究,3316名患儿,17.8% vs 15.4%,OR=0.73)以及红细胞输注(18个研究,2904名患儿,46.9% vs 38.3%,OR=0.48)风险较低。与ICC相比,UCM组早产儿的脑室出血风险(10个研究,645名患儿,22.5% vs 16.2%,OR=0.58)以及红细胞输注(9个研究,688名患儿,47.3% vs 32.3%,OR=0.36)风险较低。组间其他终点事件差异不显著,DCC与UCM组患儿预后差异不显著。
研究认为,与立即结扎脐带相比,延迟结扎脐带可降低早产儿死亡率,而延迟结扎和挤压脐带可降低早产儿脑室出血和红细胞输注风险
 
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    2021-12-29 feather89
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    2021-04-30 MedSciZeng

    #JAMA#点击进入话题查看更多相关文章 或评论时插入话题加入讨论

    0

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    2021-03-25 ms5457792007790685

    学习

    0

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    2021-03-15 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

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