Am J Clin Nutr：产前补充多种微量营养素，对后代生长和认知有什么影响？

2016-09-13 Mechront 译 MedSci原创

儿童营养不良也有可能是产前的原因，目前产前干预对儿童生长发育的影响尚不清楚。我们进行了研究，评估产前多种微量营养素(MM)补充剂对儿童成长和认知发育的影响。这项随机对照试验在孟加拉进行，评估产前MM补充剂 vs 铁叶酸(IFA)补充剂，对后代出生到24个月期间的生长影响（n = 8529）；使用贝利婴幼儿发展量表第三版对亚组(n = 734)进行了0-24个月的认知功能发育调查。数

儿童营养不良也有可能是产前的原因，目前产前干预对儿童生长发育的影响尚不清楚。我们进行了研究，评估产前多种微量营养素(MM)补充剂对儿童成长和认知发育的影响。

这项随机对照试验在孟加拉进行，评估产前MM补充剂 vs 铁叶酸(IFA)补充剂，对后代出生到24个月期间的生长影响（n = 8529）；使用贝利婴幼儿发展量表第三版对亚组(n = 734)进行了0-24个月的认知功能发育调查。

数据显示，MM组和IFA组生长迟缓（年龄相关身高z分数 (LAZ): <−2）发生率分别为31.9%和35.7%（(P < 0.001）；不过两组婴儿在头3-4个月时，LAZ增加。使用线性随机效应模型分析，产前MM暴露的儿童，相比LAZ组后代，其1个月和3个月的LAZ高出∼0.10，6个月时高出0.06。补充剂可降低1个月(RR: 0.95; 95% CI: 0.92, 0.98)和3个月(RR: 0.91; 95% CI: 0.88, 0.94)时的生长迟缓发生率。当后代6个月、12个月、以及24个月时，组间差异消失了；近50%的儿童生长迟缓。MM组与IFA组相比，从3个月到12个月，后代的出生体重和线性增长速度有所放缓，但是从12个月到24个月，该现象不复存在。在24个月大小，后代的认知、语言、运动复合评分方面，没有组间差异。

这项在孟加拉进行了的研究表明，产前和产后补充多种微量营养素，可以改善后代前三个月的LAZ，并且减少生长迟缓发生率；但是对后代2岁时的认知和运动功能等没有影响。

原始出处：

Parul Christian.et al.Effects of prenatal multiple micronutrient supplementation on growth and cognition through 2 years of age in rural Bangladesh: the JiVitA-3 Trial.Am J Clin Nutr ajcn135178; First published online September 7, 2016.

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2017-06-22 piaojinhua

#微量营养素#

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2016-09-15 qilu_qi

#产前#

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2016-09-15 lifangping

#营养素#

43 0
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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Sep 13 10:58:00 CST 2016, time=2016-09-13, status=1, ipAttribution=)]
2016-09-14 青龙偃月

学习了，赞一个！

82 0
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2016-09-14 青龙偃月

学习了，赞一个！

78 0
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2016-09-14 1dd8a7c5m95(暂无匿称)

学习了，赞一个！！！

67 0
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likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44751723931, createdName=zac posen, createdTime=Tue Sep 13 11:11:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=124618, encodeId=7b3f1246180e, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Sep 13 10:58:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=124619, encodeId=5a0b12461984, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Sep 13 10:58:00 CST 2016, time=2016-09-13, status=1, ipAttribution=)]
2016-09-14 1dd8a7c5m95(暂无匿称)

学习了，赞一个！！！

74 0
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likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44751723931, createdName=zac posen, createdTime=Tue Sep 13 11:11:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=124618, encodeId=7b3f1246180e, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Sep 13 10:58:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=124619, encodeId=5a0b12461984, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Sep 13 10:58:00 CST 2016, time=2016-09-13, status=1, ipAttribution=)]
2016-09-13 zac posen

哈哈哈哈哈哈哈哈

73 0
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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Sep 13 10:58:00 CST 2016, time=2016-09-13, status=1, ipAttribution=)]
2016-09-13 doctorJiangchao

继续学习

35 0
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likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44751723931, createdName=zac posen, createdTime=Tue Sep 13 11:11:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=124618, encodeId=7b3f1246180e, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Sep 13 10:58:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=124619, encodeId=5a0b12461984, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Sep 13 10:58:00 CST 2016, time=2016-09-13, status=1, ipAttribution=)]
2016-09-13 doctorJiangchao

继续关注

27 0

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