ECE 2016:1型糖尿病患者好好控制血糖,有利于骨骼健康

2016-06-03 Seven L 译 MedSci原创

欧洲内分泌学大会上称,改善HbA1c可能会减缓解1型糖尿病患者骨矿物质密度的损失和骨转换风险。希腊色萨利大学内分泌和代谢疾病部分的Eleftheria Barmpa和同事对107名1型糖尿病患者(平均年龄34岁,48名男性,平均糖尿病病程15年,平均BMI 23.2 kg/m²,平均 HbA1c )和95名健康对照组(年龄、性别和BMI匹配)进行了研究。使用DXA扫描监测参与者腰椎和股骨颈情况,此

欧洲内分泌学大会上称,改善HbA1c可能会减缓解1型糖尿病患者骨矿物质密度的损失和骨转换风险。

希腊色萨利大学内分泌和代谢疾病部分的Eleftheria Barmpa和同事对107名1型糖尿病患者(平均年龄34岁,48名男性,平均糖尿病病程15年,平均BMI 23.2 kg/m²,平均 HbA1c )和95名健康对照组(年龄、性别和BMI匹配)进行了研究。使用DXA扫描监测参与者腰椎和股骨颈情况,此外还检测了参与者HbA1c、骨吸收(β- CTx评估)和骨形成(以血清1型前胶原氨基端肽的总水平的评估,或 tP1NP)。糖尿病组有50名患者在1年进行了相同的检测。

数据显示,糖尿病组的基线平均BMD更低:腰椎 1.024 vs. 1.052; P =0.04、股骨颈 0.696 vs. 0.898; P =0.042;T值也更低(腰椎, –0.3 vs. 0.9; P =0.02; 股骨颈, –0.1 vs. 1.4; P = 0.038)。两组β- CTx和tP1NP检测没有差异。

第1年50名糖尿病患者中有36名患者的HbA1c下降≥ 0.5%,8名患者仍维持基线水平,6名患者升高至少 0.5%。HbA1c下降的36名患者,有3.3%的患者其腰椎BMD升高,5.6%的患者其股骨颈BMD升高,tP1NP也比基线升高(P = 0.043)。

研究人员写道:“改善血糖控制能改善1型糖尿病患者的骨密度和骨代谢,并有助于稳定这些患者的骨量。确定1型糖尿病患者骨的影响因素有助于改善该类患者的骨骼健康。”

原始出处:


Barmpa E, et al. Abstract GP88. Presented at: European Congress of Endocrinology; May 28-31, 2016; Munich.

HbA1c improvement may ease BMD loss, bone turnover in type 1 diabetes.Healio.June 2, 2016


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    2016-09-21 1e10c84am36(暂无匿称)

    文章很好,非常有益

    0

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    2016-09-17 1e10c84am36(暂无匿称)

    不错哦,会学到很多,喜欢梅斯医学文章

    0

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    2016-09-15 舒心和人

    控制血糖很重要

    0

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    2016-08-30 ylzr123

    好文,值得学习,赞!

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