JCEM:青少年哮喘和早发2型糖尿病的关系

2021-07-26 MedSci原创 MedSci原创

哮喘和早发性糖尿病的患病率都在上升,但它们之间的关联仍未明确。

哮喘和早发性糖尿病的患病率都在上升,但它们之间的关联仍未明确。

近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,研究人员旨在评估青春期哮喘与青年2型糖尿病之间可能存在的关联。

这是一项全国性、基于人群的研究,对1718541名以色列青少年(59%为男性;平均年龄为17.3岁;范围为16-19岁)进行了评估,他们在1992-2016年期间服兵役之前进行检查,数据与以色列国家糖尿病登记处相关联。哮喘诊断和严重程度由呼吸科专家根据受试者肺活量来确定。

在平均随访13年期间以上,中度至重度、轻度、非活动性和无哮喘病史的参与者2型糖尿病的发生率分别为58/9090(0.64%)、507/97059(0.52%)、114/23332(0.49%)和7095/1589060(0.44%)。在调整出生年份、性别、BMI和其他社会人口变量的模型中,以没有哮喘病史的患者为对照,各自的比值比(OR)为1.33(95%CI为1.02-1.74)、1.17(1.06-1.28)和1.09(0.9-1.31)。当分析考虑到合并症的发病率时,以及以年龄、性别、出生年份和BMI匹配的没有哮喘的人作为对照时,这种关联仍然存在。轻度和中度至重度哮喘均与35岁之前的2型糖尿病相关:OR分别为1.18(1.05-1.34)和1.44(1.05-2.00)。随着时间的推移,相关性得到了加强。当调整口服和吸入糖皮质激素使用时,效应没有改变。

由此可见,活动性哮喘的青少年患2型糖尿病的风险较高。这似乎与疾病严重程度有关,与青少年肥胖状况无关。

原始出处:

Michael Shapiro.et al.Asthma in Youth and Early-Onset Type 2 Diabetes: A Nationwide Study of 1.72 Million Israeli Adolescents.JCEM.2021.https://doi.org/10.1210/clinem/dgab542

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    2021-08-03 smallant2015
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    2022-03-28 achengzhao
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    2021-07-26 misszhang

    谢谢MedSci提供最新的资讯

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