Diabetes Metab Syndr:尿酸可作为代谢综合征标志物

2016-06-23 Mechront 译 MedSci原创

根据最近的研究发现,血清尿酸水平与代谢综合征有关,与代谢因素数量增加的水平有关。 来自印度Sardar Patel医学院的Satyendra Khichar博士和同事进行了一项病例对照研究,对100名代谢综合征成人患者和100名年龄和性别匹配的对照组(平均年龄53岁)进行了研究。 代谢综合征博阿凯高血压、向心性肥胖、高甘油三酯血症、低HDL和高血糖。研究人员根据患者的代谢综合征成分情况

根据最近的研究发现,血清尿酸水平与代谢综合征有关,与代谢因素数量增加的水平有关。

来自印度Sardar Patel医学院的Satyendra Khichar博士和同事进行了一项病例对照研究,对100名代谢综合征成人患者和100名年龄和性别匹配的对照组(平均年龄53岁)进行了研究。

代谢综合征博阿凯高血压、向心性肥胖、高甘油三酯血症、低HDL和高血糖。研究人员根据患者的代谢综合征成分情况进行分层(0, 1, 2, 3, 4或5)。高尿酸血症的定义为血清尿酸浓度在男性中至少为7 mg/dL,女性中至少为6 mg/dL;对男性和女性的尿酸浓度进行四分位数分组。

研究人员发现,代谢综合征0组到5组的平均血尿酸水平从3.08 mg/dL增加到8.01 mg/dL(P < .0001)。在血尿酸水平的四分位数,平均腰围、腰臀比、体重指数、空腹血糖、稳态模型评估的胰岛素抵抗指数(HOMA-IR)、收缩和舒张压和甘油三酯呈上升趋势;HDL呈下降趋势。

在多元回归分析中研究人员发现,66.84%的尿酸变异可以解释代谢综合征的组分(P < .0001)和尿酸对代谢综合征的贡献(P = .0015)。

“目前的研究结果清楚地证明,尿酸可以被认为是代谢综合征的一个标志物和潜在修饰剂,”研究人员写道。“这是非常容易估计且非常便宜和可靠的方法,因此,血尿酸作为一种代谢综合征的筛选生化标志物,在早期诊断和治疗中具有非常高的应用价值。”

原始出处:

Khichar S, et al. Serum uric acid level as a determinant of the metabolic syndrome: A case control study.Diabetes Metab Syndr. 2016;doi:10.1016/j.dsx.2016.06.021.

Uric acid likely marker of metabolic syndrome.Healio.June 22, 2016

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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Aug 28 15:53:00 CST 2016, time=2016-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1901400, encodeId=df02190140092, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Sun Mar 26 16:15:00 CST 2017, time=2017-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1840896, encodeId=0518184089607, content=<a 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    2017-01-21 一闲
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    2016-12-29 guojianrong
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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91491, encodeId=c30a914912f, content=学习了,以后做临床方面的研究,应该把尿酸的指标纳入进来, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cfb791835, createdName=CHBLY, createdTime=Wed Jun 29 00:13:00 CST 2016, time=2016-06-29, status=1, ipAttribution=)]
    2016-09-21 1e10c84am36(暂无匿称)

    文章很好,非常有益

    0

  5. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91491, encodeId=c30a914912f, content=学习了,以后做临床方面的研究,应该把尿酸的指标纳入进来, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cfb791835, createdName=CHBLY, createdTime=Wed Jun 29 00:13:00 CST 2016, time=2016-06-29, status=1, ipAttribution=)]
    2016-09-13 舒心和人

    看来尿酸作为第四高还是很有意义的

    0

  6. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91491, encodeId=c30a914912f, content=学习了,以后做临床方面的研究,应该把尿酸的指标纳入进来, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cfb791835, createdName=CHBLY, createdTime=Wed Jun 29 00:13:00 CST 2016, time=2016-06-29, status=1, ipAttribution=)]
    2016-08-28 ylzr123

    深度好文,值得学习,赞!

    0

  7. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91491, encodeId=c30a914912f, content=学习了,以后做临床方面的研究,应该把尿酸的指标纳入进来, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cfb791835, createdName=CHBLY, createdTime=Wed Jun 29 00:13:00 CST 2016, time=2016-06-29, status=1, ipAttribution=)]
    2016-09-20 hukaixun
  9. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91491, encodeId=c30a914912f, content=学习了,以后做临床方面的研究,应该把尿酸的指标纳入进来, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cfb791835, createdName=CHBLY, createdTime=Wed Jun 29 00:13:00 CST 2016, time=2016-06-29, status=1, ipAttribution=)]
    2016-06-29 CHBLY

    学习了,以后做临床方面的研究,应该把尿酸的指标纳入进来

    0

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