Cell Metabolism:等热量适度高脂饮食或可延长寿命!

2021-01-18 MedSci原创 MedSci原创

在控制能量的前提下,适度的高脂饮食或可通过改善炎症和氧化应激延长寿命。

减肥似乎是一个永远都“时兴”的话题。其中,控制饮食和增加锻炼是公认的最为有效的方法。然而说的简单做的难,真正能够坚持进行体育锻炼并节制饮食最后达到减肥效果的人并不多见。为此,一些新兴而又被认为“有效”的减肥方法层出不穷。其中,生酮饮食就是其中之一。

生酮饮食(ketogenic dietKD)是一种高脂肪,充足蛋白质,低碳水化合物的饮食,最早在医学上用于治疗难以控制(难治)的儿童癫痫。这种饮食强迫身体燃烧脂肪而非碳水化合物。通常,食物中的碳水化合物会转化为葡萄糖,才在体内运输。然而,如果饮食中只有少量碳水化合物,肝脏会将脂肪转化为脂肪酸和酮体。

另一方面,因为KD要求每日碳水化合物摄入量在50克以内或供能在10%以下的饮食方式。该饮食方式减肥效果源自脂肪团的脂解作用、由高蛋白质摄入带来的饱腹效应、酮中毒引起的食欲抑制以及酮体的早期利尿作用。有证据表明,生酮饮食4周内能够帮助人们平均减重10.33kg。

因此,和间歇性禁食一样,生酮饮食因其在减重方面的效果而备受人们青睐。对于三大营养物质之一的脂肪来说,它的负面影响主要来源于过量的能量摄入。那么如果能控制总能量,多摄入脂肪会有什么不良影响吗?为此,来自我国哈尔滨医科大学的研究人员进行的相关的研究,发表在最新的Cell子刊《细胞·代谢》杂志上。

研究人员在文章中写道,膳食脂肪对健康的影响一直是营养学领域最令人困扰的问题之一。很少有动物研究通过控制能量摄入来研究高脂饮食对寿命的影响。目前的膳食指南普遍推荐脂肪提供的能量不超过总能量的30%,认为这是最有助于健康的比例。但是最近有有研究表明,用其他大量营养物质代替脂肪并不能降低心脏代谢疾病的风险,因此美国膳食指南取消了“上限”要求。

研究人员将大鼠进行随机分为3组,分别给予正常的随意饮食(对照组)、相同卡路里适度高脂饮食(IHF)和高脂随意饮食(FHF)喂养2年。在该不同的喂养模式下,三组大鼠的体重、各器官重量和肌肉含量没有发现什么差异,但IHF组的内脏脂肪量最低。

在寿命方面,与对照组大鼠相比,FHF组中位寿命减少了79天,而IHF组则延长了90天。同时,对老龄大鼠进行穿梭箱实验发现,IHF组大鼠回避刺激的反应时间更短,反应率更高,说明它们的记忆能力和反应能力比较强。在跑步机测试中,IHF组跑得距离更长,说明IHF组大鼠的总体健康状况是三组中最好的,而FHF组是表现最差的。

大鼠进行尸检的结果显示,IHF组的肿瘤发生率更低,老龄大鼠的肺、肾和肝中的年龄相关病理损伤较轻。进一步,对衰老相关的生物标志物进行检测,包括,包括葡萄糖、总胆固醇、甘油三酯、白介素-6和活性氧等发现,IHF组大鼠的相关数值都显著降低。尤其是白介素-6和活性氧的降低被认为可抑制炎症和氧化应激从而延长寿命。

研究人员对脂肪代谢相关的酶进行检测后指出,IHF主要通过减少脂肪酸合成、增加脂肪酸代谢从而加速脂肪代谢。而游离脂肪酸对炎症和氧化应激都有促进作用,因此,减少总的和特定类型的游离脂肪酸可能是IHF减少炎症和氧化应激的关键一环。

综上,该研究表明,以后或许不必“望脂生畏”,在控制能量的前提下,适度的高脂饮食或可通过改善炎症和氧化应激延长寿命。

 

参考文献:

Shi D, et al. An isocaloric moderately high-fat diet extends lifespan in male rats and Drosophila. Cell Metab. 2021 Jan 7:S1550-4131(20)30672-0. doi: 10.1016/j.cmet.2020.12.017.

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    2021-11-06 一叶知秋
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    2021-03-30 维他命
  4. 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    2021-07-07 一闲
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    2021-01-26 ms5000001485212098

    怎么适度高脂

    0

  6. 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  7. 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style='color:#2F92EE;'>#Metabolism#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11597, encryptionId=d86d1159e36, topicName=Metabolism)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1a6516392333, createdName=1249859em43(暂无昵称), createdTime=Wed Jan 20 03:34:50 CST 2021, time=2021-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1598098, encodeId=69011598098b7, content=<a href='/topic/show?id=6c6f1e62c5' target=_blank style='color:#2F92EE;'>#ABO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1762, encryptionId=6c6f1e62c5, topicName=ABO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b6c918580135, createdName=闆锋旦, createdTime=Wed Jan 20 03:34:50 CST 2021, time=2021-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1613869, encodeId=c2c6161386920, content=<a href='/topic/show?id=d87e6e25687' target=_blank style='color:#2F92EE;'>#热量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67256, encryptionId=d87e6e25687, topicName=热量)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bba919440409, createdName=ms2536978994064944, createdTime=Wed Jan 20 03:34:50 CST 2021, time=2021-01-20, status=1, ipAttribution=)]
    2021-01-20 pcw111
  8. [GetPortalCommentsPageByObjectIdResponse(id=1872129, encodeId=295718e212969, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sun Oct 24 21:34:50 CST 2021, time=2021-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1888265, encodeId=9c5018882655a, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, 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  9. [GetPortalCommentsPageByObjectIdResponse(id=1872129, encodeId=295718e212969, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sun Oct 24 21:34:50 CST 2021, time=2021-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1888265, encodeId=9c5018882655a, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, 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style='color:#2F92EE;'>#Metabolism#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11597, encryptionId=d86d1159e36, topicName=Metabolism)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1a6516392333, createdName=1249859em43(暂无昵称), createdTime=Wed Jan 20 03:34:50 CST 2021, time=2021-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1598098, encodeId=69011598098b7, content=<a href='/topic/show?id=6c6f1e62c5' target=_blank style='color:#2F92EE;'>#ABO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1762, encryptionId=6c6f1e62c5, topicName=ABO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b6c918580135, createdName=闆锋旦, createdTime=Wed Jan 20 03:34:50 CST 2021, time=2021-01-20, status=1, ipAttribution=), 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    2021-01-20 闆锋旦
  10. 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GetPortalCommentsPageByObjectIdResponse(id=1613869, encodeId=c2c6161386920, content=<a href='/topic/show?id=d87e6e25687' target=_blank style='color:#2F92EE;'>#热量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67256, encryptionId=d87e6e25687, topicName=热量)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bba919440409, createdName=ms2536978994064944, createdTime=Wed Jan 20 03:34:50 CST 2021, time=2021-01-20, status=1, ipAttribution=)]