传染科指南

订阅

MedSci主页 / 所有栏目 / 传染科指南

抗结核药治疗药物监测临床应用专家共识

2021-09-08 中国呼吸科专家组（统称） 中国防痨杂志. 2021,43(09)

抗结核药

治疗药物监测（therapeutic drug monitoring,TDM）是通过测定患者体内的药物暴露、药理标志物或药效指标,利用定量药理模型,以药物治疗窗为基准,指导制订适合患者的个体化给药方案

中文标题：

抗结核药治疗药物监测临床应用专家共识

发布机构：

中国呼吸科专家组（统称）

发布日期：

2021-09-08

简要介绍：

治疗药物监测（therapeutic drug monitoring,TDM）是通过测定患者体内的药物暴露、药理标志物或药效指标,利用定量药理模型,以药物治疗窗为基准,指导制订适合患者的个体化给药方案。抗结核治疗过程中,存在药物浓度个体差异大、不良反应多等问题,可能导致治疗失败、耐药和复发。进行抗结核药物TDM,可以优化药物治疗方案,提高药物疗效,降低不良反应。为推进中国结核病TDM规范化,保证TDM的科学性、伦理性、合法性,使患者最大程度获益,经有关结核病临床和基础研究领域的专家反复讨论,就抗结核药物TDM的意义、适应证、检测方法、实施流程及TDM的质量控制等,制订了《抗结核药治疗药物监测临床应用专家共识》。 
 

相关资料下载：
[AttachmentFileName(sort=1, fileName=抗结核药治疗药物监测临床应用专家共识_陆宇.pdf)] GetToolGuiderByIdResponse(projectId=1, id=932ec1c002185ea0, title=抗结核药治疗药物监测临床应用专家共识, enTitle=, guiderFrom=中国防痨杂志. 2021,43(09), authorId=0, author=, summary=治疗药物监测（therapeutic drug monitoring,TDM）是通过测定患者体内的药物暴露、药理标志物或药效指标,利用定量药理模型,以药物治疗窗为基准,指导制订适合患者的个体化给药方案, cover=https://img.medsci.cn/2021914/1631562842434_2020535.jpg, journalId=0, articlesId=null, associationId=745, associationName=中国呼吸科专家组（统称）, associationIntro=null, copyright=0, guiderPublishedTime=Wed Sep 08 00:00:00 CST 2021, originalUrl=, linkOutUrl=, content=<div class="row"><span id="ChDivSummary" class="abstract-text" style="color: #666666;">治疗药物监测（therapeutic drug monitoring,TDM）是通过测定患者体内的药物暴露、药理标志物或药效指标,利用定量药理模型,以药物治疗窗为基准,指导制订适合患者的个体化给药方案。抗结核治疗过程中,存在药物浓度个体差异大、不良反应多等问题,可能导致治疗失败、耐药和复发。进行抗结核药物TDM,可以优化药物治疗方案,提高药物疗效,降低不良反应。为推进中国结核病TDM规范化,保证TDM的科学性、伦理性、合法性,使患者最大程度获益,经有关结核病临床和基础研究领域的专家反复讨论,就抗结核药物TDM的意义、适应证、检测方法、实施流程及TDM的质量控制等,制订了《抗结核药治疗药物监测临床应用专家共识》。&nbsp;</span></div> <div class="row">&nbsp;</div>, tagList=[TagDto(tagId=47902, tagName=抗结核药)], categoryList=[CategoryDto(categoryId=9, categoryName=传染科, tenant=100), CategoryDto(categoryId=12, categoryName=呼吸, tenant=100), CategoryDto(categoryId=85, categoryName=指南&解读, tenant=100), CategoryDto(categoryId=21100, categoryName=达仁堂循证e学界, tenant=100)], articleKeywordId=0, articleKeyword=, articleKeywordNum=6, guiderKeywordId=47902, guiderKeyword=抗结核药, guiderKeywordNum=6, haveAttachments=1, attachmentList=null, guiderType=0, guiderArea=共识, guiderLanguage=0, guiderRegion=3, opened=0, paymentType=, paymentAmount=10, recommend=0, recommendEndTime=null, sticky=0, stickyEndTime=null, allHits=3649, appHits=194, showAppHits=0, pcHits=584, showPcHits=3453, likes=2, shares=19, comments=10, approvalStatus=1, publishedTime=Tue Sep 14 03:58:39 CST 2021, publishedTimeString=2021-09-08, pcVisible=1, appVisible=1, editorId=2020535, editor=qiushida2, waterMark=0, formatted=0, memberCards=[], isPrivilege=0, deleted=0, version=2, createdBy=null, createdName=qiushida2, createdTime=Tue Sep 14 03:54:11 CST 2021, updatedBy=2020535, updatedName=qiushida2, updatedTime=Sat Jan 06 19:37:44 CST 2024, courseDetails=[], otherVersionGuiders=[], isGuiderMember=false, ipAttribution=, attachmentFileNameList=[AttachmentFileName(sort=1, fileName=抗结核药治疗药物监测临床应用专家共识_陆宇.pdf)])
抗结核药治疗药物监测临床应用专家共识_陆宇.pdf
下载请点击：
评论区 (7)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1082389, encodeId=3df9108238970, content=学习好资料！, beContent=null, objectType=guider, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0eb95611909, createdName=龙珠, createdTime=Tue Dec 21 08:48:49 CST 2021, time=2021-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1065633, encodeId=72b81065633dc, content=已学, beContent=null, objectType=guider, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc365583438, createdName=ms9000000623894544, createdTime=Sun Oct 31 23:02:26 CST 2021, time=2021-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1065632, encodeId=f082106563217, content=@@@, beContent=null, objectType=guider, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc365583438, createdName=ms9000000623894544, createdTime=Sun Oct 31 23:02:07 CST 2021, time=2021-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1055922, encodeId=5dd31055922ce, content=学习了 , beContent=null, objectType=guider, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fc4d2208236, createdName=老龙一点, createdTime=Wed Sep 29 08:06:16 CST 2021, time=2021-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1051520, encodeId=7d9810515203f, content=学习, beContent=null, objectType=guider, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=78235589459, createdName=ms3000000183190163, createdTime=Wed Sep 15 16:28:29 CST 2021, time=2021-09-15, status=1, ipAttribution=)]
    2021-12-21 龙珠

    学习好资料！

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1082389, encodeId=3df9108238970, content=学习好资料！, beContent=null, objectType=guider, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0eb95611909, createdName=龙珠, createdTime=Tue Dec 21 08:48:49 CST 2021, time=2021-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1065633, encodeId=72b81065633dc, content=已学, beContent=null, objectType=guider, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc365583438, createdName=ms9000000623894544, createdTime=Sun Oct 31 23:02:26 CST 2021, time=2021-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1065632, encodeId=f082106563217, content=@@@, beContent=null, objectType=guider, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc365583438, createdName=ms9000000623894544, createdTime=Sun Oct 31 23:02:07 CST 2021, time=2021-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1055922, encodeId=5dd31055922ce, content=学习了 , beContent=null, objectType=guider, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fc4d2208236, createdName=老龙一点, createdTime=Wed Sep 29 08:06:16 CST 2021, time=2021-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1051520, encodeId=7d9810515203f, content=学习, beContent=null, objectType=guider, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=78235589459, createdName=ms3000000183190163, createdTime=Wed Sep 15 16:28:29 CST 2021, time=2021-09-15, status=1, ipAttribution=)]
    2021-10-31 ms9000000623894544

    已学

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1082389, encodeId=3df9108238970, content=学习好资料！, beContent=null, objectType=guider, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0eb95611909, createdName=龙珠, createdTime=Tue Dec 21 08:48:49 CST 2021, time=2021-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1065633, encodeId=72b81065633dc, content=已学, beContent=null, objectType=guider, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc365583438, createdName=ms9000000623894544, createdTime=Sun Oct 31 23:02:26 CST 2021, time=2021-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1065632, encodeId=f082106563217, content=@@@, beContent=null, objectType=guider, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc365583438, createdName=ms9000000623894544, createdTime=Sun Oct 31 23:02:07 CST 2021, time=2021-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1055922, encodeId=5dd31055922ce, content=学习了 , beContent=null, objectType=guider, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fc4d2208236, createdName=老龙一点, createdTime=Wed Sep 29 08:06:16 CST 2021, time=2021-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1051520, encodeId=7d9810515203f, content=学习, beContent=null, objectType=guider, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=78235589459, createdName=ms3000000183190163, createdTime=Wed Sep 15 16:28:29 CST 2021, time=2021-09-15, status=1, ipAttribution=)]
    2021-10-31 ms9000000623894544

    @@@

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1082389, encodeId=3df9108238970, content=学习好资料！, beContent=null, objectType=guider, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0eb95611909, createdName=龙珠, createdTime=Tue Dec 21 08:48:49 CST 2021, time=2021-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1065633, encodeId=72b81065633dc, content=已学, beContent=null, objectType=guider, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc365583438, createdName=ms9000000623894544, createdTime=Sun Oct 31 23:02:26 CST 2021, time=2021-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1065632, encodeId=f082106563217, content=@@@, beContent=null, objectType=guider, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc365583438, createdName=ms9000000623894544, createdTime=Sun Oct 31 23:02:07 CST 2021, time=2021-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1055922, encodeId=5dd31055922ce, content=学习了 , beContent=null, objectType=guider, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fc4d2208236, createdName=老龙一点, createdTime=Wed Sep 29 08:06:16 CST 2021, time=2021-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1051520, encodeId=7d9810515203f, content=学习, beContent=null, objectType=guider, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=78235589459, createdName=ms3000000183190163, createdTime=Wed Sep 15 16:28:29 CST 2021, time=2021-09-15, status=1, ipAttribution=)]
    2021-09-29 老龙一点

    学习了

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1082389, encodeId=3df9108238970, content=学习好资料！, beContent=null, objectType=guider, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0eb95611909, createdName=龙珠, createdTime=Tue Dec 21 08:48:49 CST 2021, time=2021-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1065633, encodeId=72b81065633dc, content=已学, beContent=null, objectType=guider, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc365583438, createdName=ms9000000623894544, createdTime=Sun Oct 31 23:02:26 CST 2021, time=2021-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1065632, encodeId=f082106563217, content=@@@, beContent=null, objectType=guider, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc365583438, createdName=ms9000000623894544, createdTime=Sun Oct 31 23:02:07 CST 2021, time=2021-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1055922, encodeId=5dd31055922ce, content=学习了 , beContent=null, objectType=guider, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fc4d2208236, createdName=老龙一点, createdTime=Wed Sep 29 08:06:16 CST 2021, time=2021-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1051520, encodeId=7d9810515203f, content=学习, beContent=null, objectType=guider, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=78235589459, createdName=ms3000000183190163, createdTime=Wed Sep 15 16:28:29 CST 2021, time=2021-09-15, status=1, ipAttribution=)]
    2021-09-15 ms3000000183190163

    学习

    0