2013 ESMO临床实践指南：成人急性髓性白血病的诊断、治疗与随访

中文标题：

2013 ESMO临床实践指南：成人急性髓性白血病的诊断、治疗与随访

英文标题：

Acute myeloblastic leukaemias in adult patients: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

发布机构：

欧洲肿瘤内科学会

发布日期：

2013-08-22

简要介绍：

该指南为欧洲肿瘤内科学会2013年版的成人急性髓性白血病诊断、治疗与随访指南，指南介绍了成人急性髓性白血病的病因与流行病学、诊断与分子生物学、风险评估与诊断因素、治疗、个体化医疗以及疗效评估与预后。指南推荐要点：Diagnostic work-up of AML must in include morphology of peripheral blood and bone marrow, cytogenetics and molecular genetics assessed before start of therapyHLA-typing of patient and family members to plan for allogeneic stem cell transplantation where indicatedAML should only be treated in specialised and experienced centres offering a multidisciplinary approach, and the possibility of clinical trialsAML therapy with curative intent includes induction chemotherapy (incorporating an anthracycline and cytarabine), consolidation which in intermediate to high-risk patients may incorporate allogeneic stem cell transplantationAPL needs a specific therapy approach. ATRA must be started whenever in a case of leukaemia the differential diagnosis of APL is considered, and combined with anthracycline-based chemotherapy once the diagnosis of APL is confirmed