Liver spatiotemporal transcriptomics
Two studies characterize spatiotemporal transcriptional dynamics during liver homeostasis, cholestatic injury and regeneration in mice.
Two studies characterize spatiotemporal transcriptional dynamics during liver homeostasis, cholestatic injury and regeneration in mice.
By developing a modular system for precision epigenome editing, we were able to delineate the causal and quantitative role of chromatin modifications in transcription regulation. The precise effect of chromatin modifications is influenced by multiple contextual factors, including the underlying DNA sequence, transcription factor occupancy and genomic positioning.