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BoxCar increases the depth and reproducibility of diabetic urinary proteome analysis

期刊: PROTEOMICS CLINICAL APPLICATIONS, 2021; 15 (5)

Purpose Mass spectrometry-based proteomics performs well in high throughput detection of urinary proteins. Nonetheless, protein identification depth a......

Quantitative proteomics analysis identifies salivary biomarkers for early detection of pregnancy loss in a Singaporean cohort-A pilot study

期刊: PROTEOMICS CLINICAL APPLICATIONS, 2021; 15 (4)

Purpose Early pregnancy loss (EPL) is one of the most common complications encountered in clinical practice. As most of EPLs occur relatively early on......

Revealing the changes of IgG subclass-specific N-glycosylation in colorectal cancer progression by high-throughput assay

期刊: PROTEOMICS CLINICAL APPLICATIONS, 2021; 15 (2-3)

Purpose: The changes of glycosylation of different IgG subclass in colorectal cancer (CRC) were rarely investigated. The authors aimed to use a simple......

Plasma proteomics analysis of adolescent idiopathic scoliosis patients revealed by Quadrupole-Orbitrap mass spectrometry

期刊: PROTEOMICS CLINICAL APPLICATIONS, 2021; 15 (4)

Objective We aim to investigate the changes of plasma proteome among mild, severe adolescent idiopathic scoliosis (AIS) patients and healthy controls.......

Differential Protein Expression between Cystic and Solid Vestibular Schwannoma Using Tandem Mass Tag-Based Quantitative Proteomic Analysis

期刊: PROTEOMICS CLINICAL APPLICATIONS, 2020; 14 (4)

Purpose Cystic vestibular schwannoma (CVS) and solid vestibular schwannoma (SVS) are subgroups of vestibular schwannoma (VS). The tumorigenesis of CVS......

The Influence of Blood Collection Tubes in Biomarkers' Screening by Mass Spectrometry

期刊: PROTEOMICS CLINICAL APPLICATIONS, 2020; 14 (5)

Purpose Mass spectrometry is one of the rapidly developing bio-analytical techniques in recent years, and it shows that the results of biomarkers' scr......

Proteomic Analysis Reveals that EPHX1 Contributes to 5-Fluorouracil Resistance in a Human Hepatocellular Carcinoma Cell Line

期刊: PROTEOMICS CLINICAL APPLICATIONS, 2020; 14 (4)

Purpose The extensive drug resistance of hepatocellular carcinoma (HCC) has become a major cause of chemotherapy failure. A deeper understanding of th......

Proteomic Study Reveals the Involvement of Energy Metabolism in the Fast Antidepressant Effect of (2R, 6R)-Hydroxy Norketamine

期刊: PROTEOMICS CLINICAL APPLICATIONS, 2020; 14 (4)

Purpose Depression is a major disabling psychiatric disorder which causes severe financial burden and social consequences worldwide. Recently, (2R, 6R......

Bioinformatic Identification of a Breast-Specific Transcript Profile

期刊: PROTEOMICS CLINICAL APPLICATIONS, 2020; 14 (6)

Purpose To identify a breast-specific transcript profile for the first time, and present an updated bioinformatics strategy for searching tissue-speci......

Isoform 1 of Fibrinogen Alpha Chain Precursor is a Potential Biomarker for Steroid-Induced Osteonecrosis of the Femoral Head

期刊: PROTEOMICS CLINICAL APPLICATIONS, 2020; 14 (6)

Purpose Early diagnosis is crucial to increase the chances of conservation treatment for patients with steroid-induced osteonecrosis of the femoral he......

Alpha-Synuclein Dopaminylation Presented in Plasma of Both Healthy Subjects and Parkinson's Disease Patients

期刊: PROTEOMICS CLINICAL APPLICATIONS, 2020; 14 (5)

Purpose Alpha-synuclein (alpha-syn) dopaminylation can lead to the death of dopaminergic neurons in the brain and is a risk factor of Parkinson's dise......

Quantitative Proteome of Infant Stenotic Ureters Reveals Extracellular Matrix Organization and Oxidative Stress Dysregulation Underlying Ureteropelvic Junction Obstruction

期刊: PROTEOMICS CLINICAL APPLICATIONS, 2020; 14 (6)

Purpose Ureteropelvic junction obstruction (UPJO) is the most frequent cause of congenital hydronephrosis in child. To better investigate the molecula......

Glycated Plasma Proteins as More Sensitive Markers for Glycemic Control in Type 1 Diabetes

期刊: PROTEOMICS CLINICAL APPLICATIONS, 2020; 14 (2)

Purpose Glycated hemoglobin (HbA1c) is used clinically for diagnosis and therapeutic management of diabetes. However, HbA1c reflects average blood glu......

Quantitative Proteomics and Weighted Correlation Network Analysis of Tear Samples in Type 2 Diabetes Patients Complicated with Dry Eye

期刊: PROTEOMICS CLINICAL APPLICATIONS, 2020; 14 (4)

Purpose Diabetic patients are more likely to experience dry eye (DE). TMT-based proteomics and WGCNA are used to identify the differentially expressed......

Label-Free Quantitative Proteomic Profiling of LAD2 Mast Cell Releasates Reveals the Mechanism of Tween-80-Induced Anaphylactoid Reaction

期刊: PROTEOMICS CLINICAL APPLICATIONS, 2020; 14 (4)

Purpose Tween-80 is one of the most important causes resulting in anaphylactoid reaction. However, its mechanism remains unclear. Proteomic characteri......

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