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Application of Single-Domain Antibodies ("Nanobodies") to Laboratory Diagnosis

期刊: ANNALS OF LABORATORY MEDICINE, 2021; 41 (6)

Antibodies have proven to be central in the development of diagnostic methods over decades, moving from polyclonal antibodies to the milestone develop......

Detection of Spinal Muscular Atrophy Using a Duplexed Real-Time PCR Approach With Locked Nucleic Acid-Modified Primers

期刊: ANNALS OF LABORATORY MEDICINE, 2021; 41 (1)

Background: Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder mainly caused by homozygous deletions that include exon 7 o......

Reference Intervals for Thyroid-Associated Hormones and the Prevalence of Thyroid Diseases in the Chinese Population

期刊: ANNALS OF LABORATORY MEDICINE, 2021; 41 (1)

Background: Thyroid diseases are highly prevalent worldwide, but their diagnosis remains a challenge. We established reference intervals (RIs) for thy......

Commutability Assessment of Candidate External Quality Assessment Materials for Aminotransferase Activity Measurements Based on Different Approaches in China

期刊: ANNALS OF LABORATORY MEDICINE, 2021; 41 (1)

Background: Using commutable external quality assessment (EQA) materials is important for monitoring successful harmonization efforts. We assessed the......

Moving Rate of Positive Patient Results as a Quality Control Tool for High-Sensitivity Cardiac Troponin T Assays

期刊: ANNALS OF LABORATORY MEDICINE, 2021; 41 (1)

Background: A small shift in high-sensitivity cardiac troponin T (hs-cTnT) assays can lead to different result interpretation and consequent patient m......

In Vitro Activity of the Novel Tetracyclines, Tigecycline, Eravacycline, and Omadacycline, Against Moraxella catarrhalis

期刊: ANNALS OF LABORATORY MEDICINE, 2021; 41 (3)

Background: Tigecycline, eravacycline, and omadacycline are recently developed tetracyclines. Susceptibility of microbes to these tetracyclines and th......

Human B1 Cells are the Main Blood Group A-Specific B Cells That Have a Moderate Correlation With Anti-A Antibody Titer

期刊: ANNALS OF LABORATORY MEDICINE, 2020; 40 (1)

Background: Anti-carbohydrate antibody responses, including those of anti-blood group ABO antibodies, are yet to be thoroughly studied in humans. Beca......

Exploration and Validation of the Performance of Hemoglobin A1c in Detecting Diabetes in Community-Dwellers With Hypertension

期刊: ANNALS OF LABORATORY MEDICINE, 2020; 40 (6)

Background: Diabetes can complicate hypertension management by increasing the risk of cardiovascular disease (CVD) and all-cause mortality. Studies ta......

Performance of Hepatitis B Core-Related Antigen Versus Hepatitis B Surface Antigen and Hepatitis B Virus DNA in Predicting HBeAg-positive and HBeAg-negative Chronic Hepatitis

期刊: ANNALS OF LABORATORY MEDICINE, 2019; 39 (1)

Background: We examined changes in hepatitis B core-related antigen (HBcrAg) during the four sequential phases of chronic hepatitis B virus (HBV) infe......

JIF:2.63

Molecular Epidemiology and Mechanisms of 43 Low-Level Linezolid-Resistant Enterococcus faecalis Strains in Chongqing, China

期刊: ANNALS OF LABORATORY MEDICINE, 2019; 39 (1)

Background: Enterococcus faecalis strains with low-level resistance to linezolid (an oxazolidinone antibiotic) have become common. No large-scale stud......

JIF:2.63

Identification and Characterization of NDM-1-producing Hypervirulent (Hypermucoviscous) Klebsiella pneumoniae in China

期刊: ANNALS OF LABORATORY MEDICINE, 2019; 39 (2)

Background: Carbapenem-resistant hypervirulent (hypermucoviscous) Klebsiella pneumoniae (CR-HMKP) poses a significant public health challenge. We inve......

JIF:2.63

Upregulated Long Noncoding RNA LINC01234 Predicts Unfavorable Prognosis for Colorectal Cancer and Negatively Correlates With KLF6 Expression

期刊: ANNALS OF LABORATORY MEDICINE, 2019; 40 (2)

Background: LINC01234, a long noncoding RNA (lncRNA), is overexpressed in several cancers, including colorectal cancer (CRC). We investigated the role......

JIF:2.63

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