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Recent advances in the development of nanomedicines for the treatment of ischemic stroke

期刊: BIOACTIVE MATERIALS, 2021; 6 (9)

Ischemic stroke is still a serious threat to human life and health, but there are few therapeutic options available to treat stroke because of limited......

Sendai virus-based immunoadjuvant in hydrogel vaccine intensity-modulated dendritic cells activation for suppressing tumorigenesis

期刊: BIOACTIVE MATERIALS, 2021; 6 (11)

The conventional immunoadjuvants in vaccine have weak effect on stimulating antigen presentation and activating anti-tumor immunity. Unexpectedly, we ......

Bidirectional differentiation of BMSCs induced by a biomimetic procallus based on a gelatin-reduced graphene oxide reinforced hydrogel for rapid bone regeneration

期刊: BIOACTIVE MATERIALS, 2021; 6 (7)

Developmental engineering strategy needs the biomimetic composites that can integrate the progenitor cells, biomaterial matrices and bioactive signals......

High-precision, gelatin-based, hybrid, bilayer scaffolds using melt electro-writing to repair cartilage injury

期刊: BIOACTIVE MATERIALS, 2021; 6 (7)

Articular cartilage injury is a common disease in the field of orthopedics. Because cartilage has poor self-repairing ability, medical intervention is......

Sterilization and disinfection methods for decellularized matrix materials: Review, consideration and proposal

期刊: BIOACTIVE MATERIALS, 2021; 6 (9)

Sterilization is the process of killing all microorganisms, while disinfection is the process of killing or removing all kinds of pathogenic microorga......

Marginal sealing around integral bilayer scaffolds for repairing osteochondral defects based on photocurable silk hydrogels

期刊: BIOACTIVE MATERIALS, 2021; 6 (11)

Osteochondral repair remains a major challenge in current clinical practice despite significant advances in tissue engineering. In particular, the lat......

Erythrocyte membrane-camouflaged carrier-free nanoassembly of FRET photosensitizer pairs with high therapeutic efficiency and high security for programmed cancer synergistic phototherapy

期刊: BIOACTIVE MATERIALS, 2021; 6 (8)

Phototherapy has been intensively investigated as a non-invasive cancer treatment option. However, its clinical translation is still impeded by unsati......

Enhanced osteogenesis of titanium with nano-Mg(OH)(2) film and a mechanism study via whole genome expression analysis

期刊: BIOACTIVE MATERIALS, 2021; 6 (9)

Titanium (Ti) has been the most widely used orthopedic implant in the past decades. However, their inert surface often leads to insufficient osteointe......

Hypoxia-mimicking 3D bioglass-nanoclay scaffolds promote endogenous bone regeneration

期刊: BIOACTIVE MATERIALS, 2021; 6 (10)

Large bone defect repair requires biomaterials that promote angiogenesis and osteogenesis. In present work, a nanoclay (Laponite, XLS)-functionalized ......

New design to remove leukocytes from platelet-rich plasma (PRP) based on cell dimension rather than density

期刊: BIOACTIVE MATERIALS, 2021; 6 (10)

Platelet-rich plasma (PRP) can stimulate the proliferation of stem cells and have a positive effect on tissue repair. Although many commercialized PRP......

3D-printed cell-free PCL-MECM scaffold with biomimetic micro-structure and micro-environment to enhance in situ meniscus regeneration

期刊: BIOACTIVE MATERIALS, 2021; 6 (10)

Despite intensive effort was made to regenerate injured meniscus by cell-free strategies through recruiting endogenous stem/progenitor cells, meniscus......

Advances of adipose-derived mesenchymal stem cells-based biomaterial scaffolds for oral and maxillofacial tissue engineering

期刊: BIOACTIVE MATERIALS, 2021; 6 (8)

The management of oral and maxillofacial tissue defects caused by tumors, trauma, and congenital or acquired deformities has been a major challenge fo......

Gold nanorods and nanohydroxyapatite hybrid hydrogel for preventing bone tumor recurrence via postoperative photothermal therapy and bone regeneration promotion

期刊: BIOACTIVE MATERIALS, 2021; 6 (8)

Osteosarcoma is a malignant bone tumor, which often occurs in adolescents. However, surgical resection usually fails to completely remove the tumor cl......

Biomimetic inorganic-organic hybrid nanoparticles from magnesium-substituted amorphous calcium phosphate clusters and polyacrylic acid molecules

期刊: BIOACTIVE MATERIALS, 2021; 6 (8)

Amorphous calcium phosphate (ACP) has been widely found during bone and tooth biomineralization, but the meta-stability and labile nature limit furthe......

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