期刊： GENOME RESEARCH, 2021; 31 (7)
Protein-truncating variants (PTVs) have important impacts on phenotype diversity and disease. However, their population genetics characteristics in mo......
期刊： GENOME RESEARCH, 2021; 31 (4)
Single-cell RNA sequencing (scRNA-seq) technology is poised to replace bulk cell RNA sequencing for many biological and medical applications as it all......
期刊： GENOME RESEARCH, 2021; 31 (6)
Transfer RNAs (tRNAs) are essential for translation, and tRNA expression and modifications are regulated by many factors. However, the interplay betwe......
期刊： GENOME RESEARCH, 2021; 31 (7)
Thousands of species will be sequenced in the next few years; however, understanding how their genomes work, without an unlimited budget, requires bot......
期刊： GENOME RESEARCH, 2021; 31 (4)
The environment has constantly shaped plant genomes, but the genetic bases underlying how plants adapt to environmental influences remain largely unkn......
期刊： GENOME RESEARCH, 2021; 31 (5)
Single nucleotide variants (SNVs) within polyadenylation signals (PASs), a specific six-nucleotide sequence required for mRNA maturation, can impair R......
期刊： GENOME RESEARCH, 2021; 31 (4)
Heterosis or hybrid vigor is a common phenomenon in plants and animals; however, the molecular mechanisms underlying heterosis remain elusive, despite......
期刊： GENOME RESEARCH, 2021; 31 (5)
Targeted mutagenesis in model organisms is key for gene functional annotation and biomedical research. Despite technological advances in gene editing ......
期刊： GENOME RESEARCH, 2021; 31 (9)
Uniparental embryos derived from only the mother (gynogenetic [GG]) or the father (androgenetic [AG]) are unique models for studying genomic imprintin......
期刊： GENOME RESEARCH, 2021; 31 (9)
G-quadruplexes (G4s) are noncanonical DNA secondary structures formed through the self-association of guanines, and G4s are distributed widely across ......
期刊： GENOME RESEARCH, 2021; 31 (8)
Concepts of evolutionary biology suggest that morphological change may occur by rare punctual but rather large changes, or by more steady and gradual ......
期刊： GENOME RESEARCH, 2021; 31 (7)
Heterochromatin remodeling is critical for various cell processes. In particular, the "loss of heterochromatin" phenotype in cellular senescence is as......
期刊： GENOME RESEARCH, 2021; 31 (8)
R-loops are stable chromatin structures comprising a DNA:RNA hybrid and a displaced single-stranded DNA. R-loops have been implicated in gene expressi......
期刊： GENOME RESEARCH, 2021; 31 (1)
Eukaryotic gene transcription is regulated by a large cohort of chromatin-associated proteins, and inferring their differential binding sites between ......
期刊： GENOME RESEARCH, 2021; 31 (1)
Quantifying and comparing the amount of adaptive evolution among different species is key to understanding how evolution works. Previous studies have ......
