Response to IL-6 trans- and IL-6 classic signalling is determined by the ratio of the IL-6 receptor to gp130 expression: fusing experimental insights and dynamic modelling

Reeh, H; Rudolph, N; Billing, U; Christen, H; Streif, S; Bullinger, E; Schliemann-Bullinger, M; Findeisen, R; Schaper, F; Huber, HJ; Dittrich, A

Dittrich, A (reprint author), Otto von Guericke Univ, Fac Nat Sci, Inst Biol, Dept Syst Biol, Univ Pl 2, D-39106 Magdeburg, Germany.

CELL COMMUNICATION AND SIGNALING, 2019; 17 ():

Abstract

BackgroundInterleukin-6 is a pleiotropic cytokine with high clinical relevance and an important mediator of cellular communication, orchestrating both......

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