Circulation:冠脉支架血栓患者的光学相干断层扫描结果

2017-07-21 xiangting MedSci原创

在ST患者中,经常观察到支架梁未覆盖新生内膜或贴壁不良,随着支架植入和出现症状之间的时间间隔越长,两者的发生率也随之下降。

冠脉支架置入术后血栓形成(ST)是一种严重的并发症。血管内光学相干断层扫描(OCT)可以发现导致ST的机械过程。研究人员进行了一项前瞻性多中心的研究以评估ST患者的OCT结果。

纳入使用中央电话登记系统前瞻性注册登记的ST患者。在血管造影确认ST后,用频域OCT进行病变血管的OCT成像。根据标准化方案收集临床资料。在中心实验室对OCT结果进行分析。由影像裁决委员会裁定主要的结果。

231例ST患者进行了OCT成像; 14例(6.1%)的图像质量不能进行进一步分析。其余患者中,62例(28.6%)和155例(71.4%)分别出现早,晚/非常晚ST。50.3%的支架类型为新一代的药物洗脱支架。平均参考血管直径为2.9±0.6mm,平均参考血管面积为6.8±2.6mm2。在44.4%的患者中观察到支架不完全膨胀(支架扩张指数<0.8)。急性、亚急性、晚期和非常晚期支架血栓任何支架发现未覆盖(或血栓覆盖)支架梁的预计平均概率(95%置信区间)分别为99.3%(96.1%; 99.9%),96.6%(92.4%; 98.5%),34.3%(15.0%; 60.7% )和9.6%(6.2%; 14.5%),支架梁贴壁不良为21.8%(8.4%; 45.6%),8.5%(4.6%; 15.3%),6.7%(2.5%; 16.3%)和2.0% (1.2%; 3.3%)。急性ST评估最常见的主要发现是未覆盖新生内膜(66.7%),亚急性ST是未覆盖新生内膜(61.7%)和不完全膨胀(25.5%),晚期ST是未覆盖新生内膜(33.3%)和严重再狭窄(19.1%),非常晚期的ST是新生动脉粥样硬化(31.3%)和未覆盖新生内膜(20.2%)。在非常晚期ST患者中,支架未覆盖新生内膜是DES中常见的主要发现,以及裸金属支架中的新动脉粥样硬化。

在ST患者中,经常观察到支架梁未覆盖新生内膜或贴壁不良,随着支架植入和出现症状之间的时间间隔越长,两者的发生率也随之下降。最常见的发现根据支架置入的时间间隔而变化:急性/亚急性ST为支架梁未覆盖新生内膜和不完全膨胀,晚期/非常晚期ST为新动脉粥样硬化和支架梁未覆盖新生内膜。

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    2017-07-22 184****9840

    学习了谢谢分享

    0

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    2017-07-21 nannanxyy

    内容很好

    0

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