存在肾损伤史,痊愈了仍会增加女性妊娠期各种并发症的发生!

2016-12-25 MedSci MedSci原创

近日,来自马萨诸塞州总医院(MGH)肾脏科的一项新的研究发现,有过肾损伤史的孕妇,即使在怀孕前肾功能正常,其先兆子痫和其他妊娠并发症的风险也较大,该研究结果已发表于Journal of the American Society of Nephrology.。研究人员分析了24745名1998-2007年在MGH分娩过的女性的病例记录。其中24640名没有肾脏疾病史(对照组),105名女性有急性肾脏

近日,来自马萨诸塞州总医院(MGH)肾脏科的一项新的研究发现,有过肾损伤史的孕妇,即使在怀孕前肾功能正常,其先兆子痫和其他妊娠并发症的风险也较大,该研究结果已发表于Journal of the American Society of Nephrology.。

研究人员分析了24745名1998-2007年在MGH分娩过的女性的病例记录。其中24640名没有肾脏疾病史(对照组),105名女性有急性肾脏损伤史,但是怀孕时已完全恢复。

结果发现,与无肾脏疾病史的女性相比,存在急性肾脏损伤史的女性妊娠并发症的风险更大。

与对照组4%的发病率相比,存在急性肾脏损伤史的女性妊娠期先兆子痫的发病率为23%。

妊娠期方面,存在急性肾脏损伤史的女性妊娠期普遍较对照组短,分别为37.6周和39.2周,且婴儿出生时的体重过小的几率也大,分别为15%和8 %。

此外,研究人员发现,与对照组相比,存在急性肾脏损伤史的孕妇剖腹产的比例较高,分别为27%和40%。

校正一些可能存在的混杂因素后,研究人员发现,存在急性肾脏损伤史的孕妇出现不良妊娠结局的风险较对照组高2.4倍,出现先兆子痫的风险高5.9倍。

目前研究人员也无法解释既往肾脏损伤史与妊娠不良结局危险性更大关联背后的机制。但是,研究人员推测,这或与肾损伤恢复过程中小血管的变化可能影响了怀孕期间肾脏的功能。

仍需进一步的研究来证实本研究的发现,基于该研究结果,研究人员建议应密切关注存在急性肾脏损伤史的孕妇。

原始出处:

[1] Honor Whiteman. Past kidney injury may raise risk of poor pregnancy outcomes. MNT, 23 December 2016.

[2] Jessica Sheehan Tangren et al., Pregnancy outcomes following clinical recovery from acute kidney injury, Journal of the American Society of Nephrology, 22 December 2016.


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    2017-09-10 丁鹏鹏
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    2016-12-25 inter158

    无法解释既往肾脏损伤史与妊娠不良结局危险性更大关联背后的机制。

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1757762, encodeId=b0c61e5776275, content=<a href='/topic/show?id=84ba49031f9' target=_blank style='color:#2F92EE;'>#并发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49031, encryptionId=84ba49031f9, topicName=并发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a27e37327108, createdName=丁鹏鹏, createdTime=Sun Sep 10 00:32:00 CST 2017, time=2017-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251020, encodeId=8d1212510201c, content=<a href='/topic/show?id=90494486837' target=_blank style='color:#2F92EE;'>#妊娠期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44868, encryptionId=90494486837, topicName=妊娠期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Tue Dec 27 07:32:00 CST 2016, time=2016-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397112, encodeId=d482139e1125b, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Tue Dec 27 07:32:00 CST 2016, time=2016-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=165659, encodeId=78931656591b, content=无法解释既往肾脏损伤史与妊娠不良结局危险性更大关联背后的机制。, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151226/IMG567EB873985DE3928.jpg, createdBy=ea941622301, createdName=inter158, createdTime=Sun Dec 25 23:11:50 CST 2016, time=2016-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=165655, encodeId=691c16565594, content=阅读了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sun Dec 25 22:54:14 CST 2016, time=2016-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=165649, encodeId=e5be16564959, content=谢谢分享!!!!!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Sun Dec 25 22:28:57 CST 2016, time=2016-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=165633, encodeId=1059165633cf, content=肾脏疾病的后续危害居然那么严重,涨见识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=84e21956153, createdName=1e1263e3m20(暂无匿称), createdTime=Sun Dec 25 21:11:46 CST 2016, time=2016-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=165619, encodeId=a6041656195a, content=棒棒哒??????, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76491981781, createdName=1e184d7bm65(暂无匿称), createdTime=Sun Dec 25 17:48:36 CST 2016, time=2016-12-25, status=1, ipAttribution=)]
    2016-12-25 刘煜

    阅读了谢谢分享

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1757762, encodeId=b0c61e5776275, content=<a href='/topic/show?id=84ba49031f9' target=_blank style='color:#2F92EE;'>#并发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49031, encryptionId=84ba49031f9, topicName=并发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a27e37327108, createdName=丁鹏鹏, createdTime=Sun Sep 10 00:32:00 CST 2017, time=2017-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251020, encodeId=8d1212510201c, content=<a href='/topic/show?id=90494486837' target=_blank style='color:#2F92EE;'>#妊娠期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44868, encryptionId=90494486837, topicName=妊娠期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Tue Dec 27 07:32:00 CST 2016, time=2016-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397112, encodeId=d482139e1125b, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Tue Dec 27 07:32:00 CST 2016, time=2016-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=165659, encodeId=78931656591b, content=无法解释既往肾脏损伤史与妊娠不良结局危险性更大关联背后的机制。, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151226/IMG567EB873985DE3928.jpg, createdBy=ea941622301, createdName=inter158, createdTime=Sun Dec 25 23:11:50 CST 2016, time=2016-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=165655, encodeId=691c16565594, content=阅读了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sun Dec 25 22:54:14 CST 2016, time=2016-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=165649, encodeId=e5be16564959, content=谢谢分享!!!!!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Sun Dec 25 22:28:57 CST 2016, time=2016-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=165633, encodeId=1059165633cf, content=肾脏疾病的后续危害居然那么严重,涨见识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=84e21956153, createdName=1e1263e3m20(暂无匿称), createdTime=Sun Dec 25 21:11:46 CST 2016, time=2016-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=165619, encodeId=a6041656195a, content=棒棒哒??????, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76491981781, createdName=1e184d7bm65(暂无匿称), createdTime=Sun Dec 25 17:48:36 CST 2016, time=2016-12-25, status=1, ipAttribution=)]
    2016-12-25 知难而进

    谢谢分享!!!!!!!

    0

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    2016-12-25 1e1263e3m20(暂无匿称)

    肾脏疾病的后续危害居然那么严重,涨见识了

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1757762, encodeId=b0c61e5776275, content=<a href='/topic/show?id=84ba49031f9' target=_blank style='color:#2F92EE;'>#并发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49031, encryptionId=84ba49031f9, topicName=并发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a27e37327108, createdName=丁鹏鹏, createdTime=Sun Sep 10 00:32:00 CST 2017, time=2017-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251020, encodeId=8d1212510201c, content=<a href='/topic/show?id=90494486837' target=_blank style='color:#2F92EE;'>#妊娠期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44868, encryptionId=90494486837, topicName=妊娠期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Tue Dec 27 07:32:00 CST 2016, time=2016-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397112, encodeId=d482139e1125b, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Tue Dec 27 07:32:00 CST 2016, time=2016-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=165659, encodeId=78931656591b, content=无法解释既往肾脏损伤史与妊娠不良结局危险性更大关联背后的机制。, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151226/IMG567EB873985DE3928.jpg, createdBy=ea941622301, createdName=inter158, createdTime=Sun Dec 25 23:11:50 CST 2016, time=2016-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=165655, encodeId=691c16565594, content=阅读了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sun Dec 25 22:54:14 CST 2016, time=2016-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=165649, encodeId=e5be16564959, content=谢谢分享!!!!!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Sun Dec 25 22:28:57 CST 2016, time=2016-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=165633, encodeId=1059165633cf, content=肾脏疾病的后续危害居然那么严重,涨见识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=84e21956153, createdName=1e1263e3m20(暂无匿称), createdTime=Sun Dec 25 21:11:46 CST 2016, time=2016-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=165619, encodeId=a6041656195a, content=棒棒哒??????, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76491981781, createdName=1e184d7bm65(暂无匿称), createdTime=Sun Dec 25 17:48:36 CST 2016, time=2016-12-25, status=1, ipAttribution=)]
    2016-12-25 1e184d7bm65(暂无匿称)

    棒棒哒??????

    0

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