BMJ:H7N9可以在无关的两个人之间传播吗?(中国两例患者的实例报道)

2015-11-20 崔倩 译 MedSci原创

禽流感A(H7N9)病毒可以在医院的无关个体之间传染吗?

禽流感A(H7N9)病毒可以在医院的无关个体之间传播吗?

研究人员在2015年2月对中国浙江省衢州市的同一家医院两名患者进行了流行病学调查。研究人员通过实时逆转录酶(rRT)聚合酶链反应(PCR)和病毒培养对患者、密切接触者、以及当地环境进行了检查。血凝抑制和微量中和测定法用于检测针对病毒的特异性抗体。主要成果是临床数据、传染源追踪、系统进化树分析和血清学结果。

一名49岁的男子(源头患者)前往活禽市场七天后病倒了。一名57岁的男子(第二例),有慢性阻塞性肺疾病病史,与源头患者在同一个病房后5天出现像源头患者一样的流感样症状。第二例患者没有到过任何家禽市场,也没有在发病前15天内与家禽或鸟类接触。H7N9病毒在这两个病人体内被确定,后来两例患者均死亡。从这两个病人身上分离出的病毒基因序列几乎是相同的,而且与从活禽市场分离出病毒基因相似。其中38位密切接触者未发现特异性抗体。由于缺乏来自他们共有的病房采集的样本,患者之间的传输仍不清楚。尽管一些环境样本由RRT-PCR检测H7N9呈阳性,但无病毒培养。由于延迟诊断和频繁转院,从病人中采集的血清样品,和H7N9病毒的抗体无法测试。

两个不相关的个体之间在医院的H7N9传播是可能的。流感样疾病医院在监测病人时以及活家禽市场如鸡等应加强监测病毒的传染性和致病性。

原始出处:

Chun-Fu Fang,Mai-Juan Ma,Bing-Dong Zhan,et al.Nosocomial transmission of avian influenza A (H7N9) virus in China,BMJ,2015.11.19

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  1. [GetPortalCommentsPageByObjectIdResponse(id=142597, encodeId=884d14259e19, content=不错的文章,给我们提供了一种思路,综合其他报道的文章分析分析这种病毒传播的特别, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82351961337, createdName=1e137bdcm70(暂无匿称), createdTime=Sun Oct 09 12:02:28 CST 2016, time=2016-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1847772, encodeId=065e184e77277, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Fri Dec 04 13:45:00 CST 2015, time=2015-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=51061, encodeId=5bb351061cc, content=值得关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=171, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Sat Jan 02 00:21:00 CST 2016, time=2016-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=51060, encodeId=e7c25106048, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Sat Jan 02 00:20:00 CST 2016, time=2016-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1477497, encodeId=e60614e74978b, content=<a href='/topic/show?id=9f7d8411fc' target=_blank style='color:#2F92EE;'>#H7N9#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8411, encryptionId=9f7d8411fc, topicName=H7N9)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e1f27379114, createdName=ms117281293605716, createdTime=Sat Nov 21 23:45:00 CST 2015, time=2015-11-21, status=1, ipAttribution=)]
    2016-10-09 1e137bdcm70(暂无匿称)

    不错的文章,给我们提供了一种思路,综合其他报道的文章分析分析这种病毒传播的特别

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=142597, encodeId=884d14259e19, content=不错的文章,给我们提供了一种思路,综合其他报道的文章分析分析这种病毒传播的特别, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82351961337, createdName=1e137bdcm70(暂无匿称), createdTime=Sun Oct 09 12:02:28 CST 2016, time=2016-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1847772, encodeId=065e184e77277, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Fri Dec 04 13:45:00 CST 2015, time=2015-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=51061, encodeId=5bb351061cc, content=值得关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=171, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Sat Jan 02 00:21:00 CST 2016, time=2016-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=51060, encodeId=e7c25106048, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Sat Jan 02 00:20:00 CST 2016, time=2016-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1477497, encodeId=e60614e74978b, content=<a href='/topic/show?id=9f7d8411fc' target=_blank style='color:#2F92EE;'>#H7N9#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8411, encryptionId=9f7d8411fc, topicName=H7N9)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e1f27379114, createdName=ms117281293605716, createdTime=Sat Nov 21 23:45:00 CST 2015, time=2015-11-21, status=1, ipAttribution=)]
    2015-12-04 gaoxiaoe
  3. [GetPortalCommentsPageByObjectIdResponse(id=142597, encodeId=884d14259e19, content=不错的文章,给我们提供了一种思路,综合其他报道的文章分析分析这种病毒传播的特别, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82351961337, createdName=1e137bdcm70(暂无匿称), createdTime=Sun Oct 09 12:02:28 CST 2016, time=2016-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1847772, encodeId=065e184e77277, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Fri Dec 04 13:45:00 CST 2015, time=2015-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=51061, encodeId=5bb351061cc, content=值得关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=171, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Sat Jan 02 00:21:00 CST 2016, time=2016-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=51060, encodeId=e7c25106048, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Sat Jan 02 00:20:00 CST 2016, time=2016-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1477497, encodeId=e60614e74978b, content=<a href='/topic/show?id=9f7d8411fc' target=_blank style='color:#2F92EE;'>#H7N9#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8411, encryptionId=9f7d8411fc, topicName=H7N9)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e1f27379114, createdName=ms117281293605716, createdTime=Sat Nov 21 23:45:00 CST 2015, time=2015-11-21, status=1, ipAttribution=)]
    2016-01-02 xyfg98

    值得关注

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=142597, encodeId=884d14259e19, content=不错的文章,给我们提供了一种思路,综合其他报道的文章分析分析这种病毒传播的特别, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82351961337, createdName=1e137bdcm70(暂无匿称), createdTime=Sun Oct 09 12:02:28 CST 2016, time=2016-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1847772, encodeId=065e184e77277, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Fri Dec 04 13:45:00 CST 2015, time=2015-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=51061, encodeId=5bb351061cc, content=值得关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=171, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Sat Jan 02 00:21:00 CST 2016, time=2016-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=51060, encodeId=e7c25106048, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Sat Jan 02 00:20:00 CST 2016, time=2016-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1477497, encodeId=e60614e74978b, content=<a href='/topic/show?id=9f7d8411fc' target=_blank style='color:#2F92EE;'>#H7N9#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8411, encryptionId=9f7d8411fc, topicName=H7N9)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e1f27379114, createdName=ms117281293605716, createdTime=Sat Nov 21 23:45:00 CST 2015, time=2015-11-21, status=1, ipAttribution=)]
    2016-01-02 xyfg98

    好文章

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=142597, encodeId=884d14259e19, content=不错的文章,给我们提供了一种思路,综合其他报道的文章分析分析这种病毒传播的特别, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82351961337, createdName=1e137bdcm70(暂无匿称), createdTime=Sun Oct 09 12:02:28 CST 2016, time=2016-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1847772, encodeId=065e184e77277, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Fri Dec 04 13:45:00 CST 2015, time=2015-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=51061, encodeId=5bb351061cc, content=值得关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=171, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Sat Jan 02 00:21:00 CST 2016, time=2016-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=51060, encodeId=e7c25106048, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Sat Jan 02 00:20:00 CST 2016, time=2016-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1477497, encodeId=e60614e74978b, content=<a href='/topic/show?id=9f7d8411fc' target=_blank style='color:#2F92EE;'>#H7N9#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8411, encryptionId=9f7d8411fc, topicName=H7N9)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e1f27379114, createdName=ms117281293605716, createdTime=Sat Nov 21 23:45:00 CST 2015, time=2015-11-21, status=1, ipAttribution=)]

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